Malcom R. Alison, Richard Poulsom, Rosemary Jeffery, Amar P. Dhillon, Alberto Quaglia, Joe Jacob, Marco Novelli, Grant Prentice, Jill Williamson, and Nicholas A. Wright, "Cell Differentiation: Hepatocytes from Non-Hepatic Adult Stem Cells," Nature, Vol. 406, p. 257 (July 20, 2000)


Stem cells are undifferentiated long-lived cells that are capable of many rounds of division. Here we show that adult human liver cells can be derived from stem cells originating in the bone marrow or circulating outside the liver, raising the possibility that blood-system stem cells could be used clinically to generate hepatocytes for replacing damaged tissue.