December 6-10, 1999

Sponsorship is still being sought for this Course. Please contact us if you have suggestions for potential sponsors.

Perperdine University
Los Angeles, California

Objective: To provide physicians, nurse practitioners, and other healthcare professionals with the latest theoretical and clinical approaches to Anti-Aging Medicine. A Certificate of Completion for all students and "32.5" Category I Units of CME Credit will be awarded to those physicians who successfully complete the course.

A. Faculty:

James E. Birren, Ph.D., Director, Borun Center for Gerontological Research and Deputy Director UCLA Center for Aging Research
L. Stephen Coles, M.D., Ph.D., U.S.C. (Monday and Friday)
Bruce N. Ames, Ph.D., UC Berkeley (Tuesday Noon)
Caleb E. Finch, Ph.D., Andrus Gerontology Center, USC (Monday Morning)
Arnold Fox, M.D., Author (Wednesday)
Steven B. Harris, M.D., U.C.L.A. (Tuesday Afternoon)
Leonard Hayflick, Ph.D., Anatomy, U.C.S.F. (Proposed Monday Luncheon Speaker)
Lord Lee-Benner, M.D., Chairman, World Health Foundation (Thursday and Friday)
Raymond Sahelian, M.D., Author (Thursday Luncheon Speaker)
J. Edwin Seegmiller, M.D., Associate Director, Stein Institute on Aging, UCSD
Murray Susser, M.D., Author (Wednesday Luncheon Speaker)
Karlis Ullis, M.D., U.C.L.A. (Thursday and Friday)
Roy Walford, M.D., Pathology Dept., U.C.L.A. (Tuesday Luncheon Speaker)

B. Proposed Outline for the Course Curriculum:

Five days: 9:00 AM - 5:30 PM with one hour for lunch at Noon and two 15-minute breaks per day, totals 35 hours of instruction. A Final Exam will be administered on last day.

PROGRAM: Anti-Aging Medicine ___________________________________________________________________________

Monday, December 6th

7:00 AM Registration and Distribution of Course Materials
(Continental Breakfast)

9:00 AM -- Welcome and Introduction
J. Edwin Seegmiller, M.D., Associate Director, The Sam and Rose Stein Institute for
Research on Aging, UCSD Medical School

9:15 AM "Theoretical Foundations and the History of Anti-Aging Medicine"
L. Stephen Coles, M.D., Ph.D., Computer Sciences Corp.

A. Charter of the American Academy of Anti-Aging Medicine

B. Definitions: Gerontology, Geriatrics, Longevity, and Anti-Aging Medicine

1. Epidemiology: Gompertz's Law and Historical Human Survival Curves
Biblical Patriarchs (long ago) and the Mythology of Shangri La (far away)
Guinness Book of Records vs. the Theoretical Maximum Life Span
Exponential Decay for Glass Tumblers
Biological Wild Type vs. Zoological Curves
Maximum Life Span vs. Metabolic Rate for various species
Types of Intervention: Rectangularizing vs. genuine Right-Shift (lambda-shift)

2. Who were the Historically-Important Researchers in Gerontology?
Francis Bacon, Benjamin Gompertz, August Weismann, Raymond Pearl,
Leo Szilard, Alexis Carrel, Clive McKay, Rudolph Zahn, Nathan W. Shock,
and Alex Comfort.

3. Who are the Acknowledged Current-Day World-Class Researchers?
Bernard L. Strehler, Leonard Hayflick, Roy Walford, Denham Harman,
Bruce N. Ames, Takashi Makinodan, Walter Pierpaoli, William Regelson,
Caleb E. Finch, Michael R. Rose, Allan Goldstein, James F. Fries,
Richard Weindruch, and others.

4. Who are the Self-Appointed Quacks, Frauds, and Charlatans?
Historical: Ponce de Leon, Charles-Edouard Brown-Sequard, Serge Veronoff,
Elie Metchnikoff, Eugen Steinach, Alexander Bogomoletz, etc.;
Contemporary: Paul Niehans, Ana Aslan, Deepak Chopra, and many others.

10:30 AM Coffee Break and Visit Exhibits

10:45 AM
Prof. Caleb E. Finch, Ph.D., Andrus Gerontology Center, USC

C. Biological Theories of Aging and Senescence

1. Darwinian Natural Selection as the Basis for the Longevity of a Species; Mutations;
(Reproductive fitness in the context of the predator/prey food chain; Sexuality;
Antagonistic Pleiotropy: Certain genes may have opposite effects on fitness at
different times in the species' life cycle. Optimizing fecundity vs. mortality vs.
speciation. Chimpanzees have a 98% genomic homology with humans)

2. Multifactorial Genetics vs. Environment
a. Evidence from Identical Twins Reared Apart
b. Evidence from Centenarians

3. The Shrinking Homeostatic Envelope secondary to Oxidative Stress and Free Radicals
(Collagen Cross-Linkage is analogous to the slow tanning of leather)

4. Cellular Clocks (Chromosomal Telomere Shortening and Mitotic Limits)
(Germ Line vs. Somatic Cells in vivo)(Immortal cell lines in vitro)

5. Hormonal Clocks within the Neuro-Endocrine Axis (Male vs. Female)

6. Immune Surveillance (Cancer vs. Autoimmunity)

7. Somatic Mutation

8. Programmed Senescence (Salmon)

9. Metabolic Wear-and-Tear/Rate-of-Living (Burning the Candle at Both Ends)
(Wear Out vs. Rust Out)

10. Development and Aging with and without Repair (fruit flies vs. salamanders)

11. Cartoons of Accelerated Aging (Progeria [Hutchinson/Gilford Syndrome],
Werner's Syndrome, etc.)

12. Cartoons of Retarded Aging (Dietary Restriction)

Noon: "Telomerase and the Cellular Clock"
Prof. Leonard Hayflick, Ph.D., UC San Francisco

1:00 PM Lunch

2:00 PM

D. Patient-Recognized Symptoms of Aging

1. Sensory Loss (diminished hearing, vision, smell, taste, etc.)

2. Skin Wrinkling (pigmented age spots, increased dryness)

3. Hair Loss (loss of pigment [greying], male-pattern baldness)

4. Lethargy (fatigue and diminished stamina)

5. Memory Disorders (noun retrieval)

6. Sleep Disorders (shifts in circadian/diurnal rhythm)

7. Mood Disorders (neuroses, anxiety, perseveration, OCD, bipolar)

8. Sexual Disorders (menopause, decreased libido, impotence)

E. Patient-Inspired Medical Treatments

1. Cosmetic Interventions (plastic surgery [face lifts], liposuction, chemical peels,
hair implants, etc.)

2. Drugs (Sleeping Pills, Stimulants, Aphrodisiacs, Skin Creams)

3. New Age Interventions

F. True Diseases Underlying Aging (Chronic vs. Acute Disease and "Compression of

1. Heart Disease

2. Cancer

3. Stroke

4. Arthritis

5. Diabetes

6. Osteoporosis

7. Parkinsons Disease

8. Organic Brain Syndrome (OBS) and the Senile Dementias
(However, the complete elimination of all such recognized diseases will not produce a lambda-shift)

3:15 PM Coffee Break and Visit Exhibits

3:30 PM

G. Biomarkers of Aging

1. Physical Parameters (Baltimore Longitudinal Study: lung capacity, athletic
performance, wrinkling/tenting of the skin that can be measured quantitatively)

2. Age-related changes in Total Body Composition (tissue/fluid compartments,
increased fat, decreased muscle, and bone density)

3. Laboratory Parameters (bone marrow, hormonal)

4. Commercially-Available Hardware/Software for estimating
Chronological vs. Physiological Age -- H-SCAN

5:15 PM Adjournment ____________________________________________________________________________

Tuesday, December 7th


9:00 AM "Rapid Review of the Basic Sciences"
Prof. Bruce N. Ames, Ph.D., Biochemistry and Molecular Biology Dept., U.C. Berkeley

A. Biochemistry and Molecular Biology

1. DNA, RNA, and Protein Synthesis

2. Membrane Physiology

3. Mitochondria and Metabolic Pathways

4. Antioxidant Enzymes (Glutathione Peroxidase [reductase, transferase], Catalase,
Superoxide Dismutase [SOD], DT diaphorase, lipoic acid, uric acid)

5. The Human Genome Program

10:30 AM Coffee Break and Visit Exhibits

10:45 AM

B. Physiology

1. Cardiovascular

2. GI and Kidney

3. CNS

Noon: "Evidence of Anti-Aging Interventions Using Nutrient-Rich, Calorically-Restricted
Diets in Mice, Monkeys, and Biospherians"
Prof. Roy Walford, M.D., Pathology Department, U.C.L.A.

1:00 PM Lunch


2:00 PM

"Oxidants, Anti-Oxidants and Degenerative Diseases of Aging"
Prof. Bruce N. Ames, Ph.D., Biochemistry and Molecular Biology Dept., U.C. Berkeley

4:15 PM Coffee Break and Visit Exhibits

C. Pathology
Dr. David Solomon, M.D., UCLA

1. Gross Failures of an Organism (What gets written on Death Certificates)

2. Subsystem Failure (What gets written on Autopsy Reports)
(Cardiovascular, Musculoskeletal, Nervous, Endocrine, Immune, GI/Urinary)

3. Systemic Failure (Atherosclerosis, Embolism, and Stroke)

4. Valvular Failure (stenosis and/or incompetence) and Arrhythmias

5. Tissues (Histology, Loss of Normal Architecture)

6. Cells (Cytology, Necrosis vs. Apoptosis, Lipofuscin Pigment, Heinz Bodies)

7. Organelles (Bilayer Lipid Membranes in the Cytoplasm [Endoplasmic Reticulum
{Smooth and Rough}], Mitochondria, Vacuoles, Nucleus)

8. mRNA, Ribosomes, Vaults

9. Chromosomes (arms [p,q], centromeres, telomeres [{TTAGGG}n], crossovers,
histones, DNA, nucleotides, point mutations [insertions, deletions, substitutions])

D. Pharmacology

1. Routes of Drug Administration

2. Drug Absorption, Metabolism, and Excretion (pharmachokinetic half-life)

3. Drug/Drug Interactions

5:30 PM Adjournment ____________________________________________________________________________

Wednesday, December 8th


9:00 AM "Clinical Practice"
Karlis Ullis, M.D., UCLA

A. Life Style Choices and Maintaining a Commitment to a Personal Anti-Aging Program

B. Stress Mitigation and Cortisol/Immune Levels

10:30 AM Coffee Break and Visit Exhibits

10:45 AM

C. Exercise: Art and Science (resistance training, over training)

Noon: "Chelation Therapy and Heavy Metal Poisoning"
Dr. Murray Susser, M.D., Santa Monica

1:00 PM Lunch


2:00 PM

D. "Nutrition"
Steven B. Harris, M.D., Bio Preservation; Salt Lake City, Utah

1. Total Caloric Intake, Food Groups, Obesity, Anorexia, and the Value of Dieting

2. Vitamins (especially Antioxidants [E, C, Beta Carotine, CoQ-10, Selenium],
Chromium Picolinate, What are the MDRs?)

3. Minerals (Boron, Calcium, Chloride, Cobalt, Copper, Iodine, Iron, Magnesium,
Manganese, Molybdenum, Nickel, Phosphorus, Potassium, Silicon, Sodium, Tin,
Vanadium, and Zinc)

4. Phytochemicals ("Eat your broccoli!", Green Tea, Ginkgo Biloba, Grape Seed Extract)

5. Healthy Meal Preparation (Home)

6. How to Eat Out (Restaurants [always choose fish, avoid Sunday brunches])

3:15 PM Coffee Break and Visit Exhibits

3:30 PM

E. Smart Drugs and Cognitive Enhancement

1. Selegiline (Deprenyl [Eldepryl])

2. Hydergine (Ergoloid Mesylate)

3. Vasopressin (Diapid)

4. Dilantin (DPH)

5. Piracetam (Oxiracetam)

6. Centrophenoxine (Lucidril)

5:15 PM Adjournment ____________________________________________________________________________

Thursday, December 9th


9:00 AM "Hormone Replacement Therapy"
Dr. Christopher B. Heward, Ph.D., Emerald Labs, Inc.

A. Hypothalamic/Pituitary Hormones (hGH/IGF-1/Peptidyl and Non-Peptidyl Secretogogues)

B. Adrenal/Gonadal Hormones (Testosterone/Estrogen/Progesterone)[RU486]

10:30 AM Coffee Break and Visit Exhibits

10:45 AM

C. Other Adrenal-Gland Hormones (DHEA-s, Cortisol and its relation to stress/anger)

D.Thymic Hormones (57 Different Varieties)

Noon: "The Pineal Gland, Melatonin, and Aging"
Raymond Sahelian, M.D., Marina del Rey, California

1:00 PM Lunch


2:00 PM

E. Pancreatic Hormones (Insulin, Glucagon) [Metformin (Glucophage)]

F. Thyroid (Thyroxin and the metabolic set point)

G. Parathyroid (PTH/Calcitonin)

3:15 PM Coffee Break and Visit Exhibits

3:30 PM

H. Neurotransmitters (the burden of cluttering your brain with unwanted memories; sleep)

I. Laboratory Values Needed to Establish Custom Dose Recommendations
(Oxidative Stress Profiles)

5:15 PM Adjournment ____________________________________________________________________________

Friday, December 10th


9:00 AM "How to Establish a Practice in Anti-Aging Medicine"

A. Biomarkers and Monitoring the "Rate of Aging" in your Patient Population

10:30 AM Coffee Break and Visit Exhibits

10:45 AM

B. An endorsed clinical program for affiliated practitioners

1:00 PM Lunch


2:00 PM

C. Marketing

1. How to create a custom VHS Video Tape to market your custom program

3:15 PM Coffee Break and Visit Exhibits

3:30 PM

2. How to create a custom World Wide Web (WWW) Home Page on the Internet

3. Final Exam (two hours)

6:00 PM Adjournment _____________________________________________________________________________

C. Proposed Syllabus:

Day 1:

1. James F. Fries and Lawrence M. Crapo, Vitality and Aging (W. H. Freeman and Company, San Francisco, California; 1981).

2. Caleb E. Finch, Longevity, Senescence, and the Genome (The University of Chicago Press, Chicago, Illinois; 1990).

3. Michael R. Rose, Evolutionary Biology of Aging (Oxford University Press, Inc., New York; 1991).

4. Institute of Medicine, Extending Life, Enhancing Life: A National Research Agenda on Aging (National Academy Press, Washington, D.C.; 1991).

5. Leonard Hayflick, How and Why We Age (Ballantine Books, New York; 1994).

6. Robert E. Ricklefs and Caleb E. Finch, Aging: A Natural History (Scientific American Library, New York; 1995).

7. Michael Fossel, Reversing Human Aging (William Morrow and Company, Inc., New York, New York; 1996).

8. Ronald M. Klatz, Ed., Advances in Anti-Aging Medicine, Vol. 1 (Mary Ann Liebert, Inc., Larchmont, New York; 1996).

9. Ronald M. Klatz and Robert Goldman, Eds., The Science of Anti-Aging Medicine (American Academy of Anti-Aging Medicine, Colorado Springs, Colorado; 1996).

10. Lewis Wolpert, The Triumph of the Embryo (Oxford University Press, New York; 1991).

11. Errol C. Friedberg, Graham C. Walker, Wolfram Siede, DNA Repair and Mutagenesis (ASM Press, Washington, D.C.; 1995).

12. Denham Harman, "Aging and Disease: Extending Functional Life Span," pp. 321-336, K. Kitani, A. Aoba, and S. Goto, eds., Pharmacological Intervention in Aging and Age-Associated Disorders, Vol. 786 (Annals of the New York Academy of Sciences, New York; 1996).

13. Ronald M. Klatz and Robert Goldman, Eds., Anti-Aging Medical Therapeutics, Vol. I (Health Quest Publications, Marina del Rey, California; 1997).

14. Ronald M. Klatz and Robert Goldman, Eds., Anti-Aging Medical Therapeutics, Vol. II (Health Quest Publications, Marina del Rey, California; 1998).

Day 2:

1. Imre Zs.-Nagy, The Membrane Hypothesis of Aging (CRC Press, Boca Raton, Florida; 1994).

2. Paola S. Timiras, Ed., Physiological Basis of Aging and Geriatrics, 2nd Edition (CRC Press, Inc., Boca Raton, Florida; 1994).

3. Paola S. Timiras, Wilbur B. Quay, and Antonia Vernadakis, Hormones and Aging (CRC Press, Boca Raton, Florida; 1995).

4. Paola S. Timiras, Ed., Advances in Cell Aging and Senescence (JAI Press, CT; 1995).

5. Raymond Tallis, et al, eds., Brocklehurst's Text Book of Geriatric Medicine and Gerontology, 5th Edition (Churchill Livingstone, Harcourt Brace & Co., Ltd., New York; 1998).

6. Alvaro Macieira-Coelho, Ed., Molecular Basis of Aging (CRC Press, Inc., Boca Raton, Florida; 1995).

7. Kelvin J. A. Davies and Fulvia Ursini, eds., The Oxygen Paradox (CLEUP University Press, Padova, Italy; 1995).

Day 3:

1. Waneen W. Spirduso, Physical Dimensions of Aging (Human Kinetics, Champaign, Illinois; 1995).

2. William R. Raulkner and Samuel Meites, Geriatric Clinical Chemistry, Reference Values (American Association for Clinical Chemistry, Washington, D.C.; 1993).

3. N. Orentreich, J. A. Zimmerman, and J. R. Matias, Practical Handbook of Human Biological Age Determination, pp. 391-396 (CRC Press, Boca Raton, FL; 1994).

4. Melvin R. Werbach, Nutritional Influences on Illness: A Sourcebook of Clinical Research, 2nd Edition (Third Line Press, Inc., Tarzana, California; 1996).

Day 4:

1. Raymond Sahelian, Melatonin: Nature's Sleeping Pill (Be Happier Press; Marina del Rey, California; 1995).

2. Walter Pierpaoli, William Regelson, and Carol Colman, The Melatonin Miracle: Nature's Age-Reversing, Disease-Fighting, Sex-Enhancing Hormone (Simon and Schuster, New York; 1995).

3. Russel J. Reiter and Jo Robinson, Melatonin: Your Body's Natural Wonder Drug (Bantam Books, New York; 1995).

4. Thomas J. Moore, Lifespan: Who Lives Longer and Why (Simon and Schuster, New York; 1993).

5. Dan Georgakas, The Methuselah Factors: Learning from the World's Longest Living People (New Edition, Academy Chicago Publishers, Chicago, Illinois; 1995).

6. John J. Medina, The Clock of Ages: Why We Age, How We Age, and Winding Back the Clock (Cambridge University Press, New York; 1996).

7. Ronald Klatz and Robert Goldman, Stopping the Clock: Dramatic Breakthroughs in Anti-Aging and Rejuvenation Techniques (Keats Publishing, Inc., New Canaan, Connecticut; 1996).

8. Michael Colgan, Hormonal Health: Nutritional and Hormonal Strategies for Emotional Well-Being and Intellectual Longevity (Apple Publishing, Vancouver, British Columbia, Canada; 1996).

9. Francis L. Bellino, et al, eds, Hehydroepiandrosterone (DHEA) and Aging, Annals of the New York Academy of Sciences, Vol. 774 (New York Academy of Sciences, New York; 1995).

10. Ray Sahelian, DHEA: A Practical Guide (Avery Publishing Group, Garden City Park, New York; 1996).

11. William Regelson and Carol Colman, The Super Hormone Promise: Nature's Antidote to Aging (Simon and Schuster, New York; 1996).

12. Stephen Cherniske, The DHEA Breakthrough: Look Younger, Live Longer, Feel Better (Ballantine Books, New York; 1996).

13. Ronald Klatz and Carol Kahn, Grow Young with HGH (Harper Collins, New York; 1997).

14. Karlis Ulis and Greg Ptacek, Age Right: Turn Back the Clock with a Proven Personalized Anti-Aging Program (Simon and Schuster, New York; 1999).

Day 5:

1. Larry Aronson, HTML: Manual of Style-- A Clear Concise Reference for the Hyper Text Markup Language (Ziff-Davis Press; Emeryville, California; 1994).

2. Lawrence Lemay, Teach Yourself Web Publishing with HTML in a Week (SAMS Publishing; Indianapolis, Indiana; 1995).

3. Ian S. Graham, HTML Sourcebook: A Complete Guide to HTML (John Wiley and Sons, Inc.; New York, New York; 1995).

A bibliography of 50-60 standard references will be handed out on the first day of the course.